Ferinject (ferric carboxymaltose) is an intravenous iron preparation administered via infusion, not transfusion. The recommended infusion rate varies by dosage, ranging from a minimum of 6 minutes for doses between 200–500 mg to at least 15 minutes for doses between 0.5–1 g (500-1000 mg). All doses must be diluted in 0.9% Sodium Chloride.
Understanding Ferinject Administration
Ferinject is a commonly prescribed intravenous (IV) iron therapy used to treat iron deficiency anemia when oral iron is ineffective or not tolerated. Unlike a blood transfusion, which involves administering blood or blood components, Ferinject delivers elemental iron directly into the bloodstream through a slow drip, known as an infusion. This method ensures efficient delivery of iron to replenish body stores and improve hemoglobin levels. For more general information on iron deficiency and its treatments, you can consult reputable health resources like the Mayo Clinic.
Recommended Infusion Rates for Ferinject
Accurate and controlled infusion rates are critical to ensure both the efficacy and safety of Ferinject administration. The manufacturer provides specific guidelines for dilution and minimum infusion times based on the iron dose.
Dosage and Infusion Time Table
The following table outlines the recommended dilution volumes and minimum infusion times for Ferinject:
| Ferinject Dose | Dilution Volume (0.9% Sodium Chloride) | Minimum Infusion Time |
|---|---|---|
| 200–500 mg | Up to 100 mL | At least 6 minutes |
| 0.5–1 g | Up to 250 mL | At least 15 minutes |
It is crucial to adhere to these guidelines to minimize potential infusion-related reactions and ensure patient comfort. The phrase "at least" indicates that the infusion can be administered over a longer duration if clinically appropriate, but never faster than the specified minimum time.
Important Considerations for Administration
Proper administration of Ferinject involves several key steps and considerations beyond just the infusion rate:
- Diluent: Ferinject must be diluted exclusively in 0.9% Sodium Chloride (normal saline). Other diluents should not be used.
- Preparation:
- For doses of 200–500 mg, the Ferinject should be diluted in a volume of 0.9% Sodium Chloride up to 100 mL.
- For doses of 0.5–1 g (500–1000 mg), the Ferinject should be diluted in a volume of 0.9% Sodium Chloride up to 250 mL.
- Monitoring: Patients should be carefully monitored during and immediately after the infusion for any signs of adverse reactions, such as hypersensitivity reactions, changes in blood pressure, or dizziness. Facilities for managing anaphylactic reactions should always be available.
- Professional Oversight: Ferinject should only be administered by healthcare professionals experienced in intravenous iron administration and equipped to manage potential adverse events.
- Individual Patient Needs: While general guidelines exist, individual patient factors such as age, comorbidities, and tolerance may influence the exact administration approach, always under the discretion of a healthcare provider.
Intravenous Iron Administration
